YT for next: Youtube daily Nov 16 2017

What a steady hand, Cristina.

Let's go out...

Otherwise we're going to stain everything.

This coffee smells a lot, dude.

Show me the Zombie Dance.

Don't kill me, please...

With the knife.

Shit, I did it wrong again.

It's SO evident!

Again!

Hi!

It looks like that movie...

of the guy that shows his face.

Hi! Surprise!

Don't say anything.

Don't laugh.

Don't grab me!

It's better if you don't grab her.

It never works.

Don't grab me. It makes me laugh.

Don't grab me!

Ow! Don't grab me!

The "camera" (mispronounced) antishake...

The camera! (mispronounced)...

The CA-ME-RA.

Although it was on a tripod...

the camera anti-shake tried...

You mispronounced camera again.

Again? Fuck! I didn't notice.

You're showing your knickers!

it occurred to me to use...

this crappy camera...

to touch myself.

To touch myself!

I said to touch myself!

Blooper!

NOOOO!

What are you doing?

It makes me laugh.

Don't grab me. It makes me laugh!

Should I stop or what?

The sheet blew away.

He's about to enter in the shot.

Fuck!

Stop, he's behind you.

Again!

It doesn't matter! Don't touch it!

Jose Maria I've to go.

It's perfect! Stop!

I said it perfectly!

What's up Cristina?

Oh Cris, I said it perfectly.

Stop hitting me.

I could't read it.

What happened?

Oh my God!

For more infomation >> Tifita - Bloopers 2 (Tomas Falsas) - Duration: 5:33.

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FDA CDER Regulatory Science: Real World Evidence - Duration: 3:56.

Real-world evidence is information on patient's health and health care that comes from multiple

sources within and outside the clinical setting.

Examples include electronic health records, claims and billing data from health plans,

medical product or disease registries, and data gathered from personal devices that people

might wear or health applications.

Well, personal devices like fitness tracking apps can provide information about vital health

measures like blood pressure and heart rate.

That could add more information to the total picture of the patient's health.

Electronic health records and claims data tell us about conditions people have, the

stages of their disease, the treatments they are receiving, and some about how they're

responding.

Being able to take advantage of data other than those in those traditional trials increases

our options for research and helps us be able to gather more information.

And access to these data could increase the speed and efficiency of setting up trials.

Right now, our Sentinel system uses claims data from hundreds of millions of Americans

to look for safety signals related to marketed drugs.

The FDA is also collaborating with Google to identify whether search engine data—for

example, web search logs—can identify and evaluate previously unreported adverse reactions

and detect safety signals earlier than current FDA strategies.

The FDA and PatientsLikeMe, which is a large online patient network with about half a million

members reporting on their experiences with more than 2,500 conditions, are collaborating

to explore how patient-generated health data can give new insights into drug safety.

While real-world data can augment and increase the effectiveness of clinical research, real-world

data cannot completely replace the gold standard of controlled clinical trials for assessing

efficacy and safety of new drugs.

The accuracy and completeness of data in electronic health record systems may be highly variable

from site to site and even within a single health care institution, and we have certainly

seen this.

Well, CDER believes that real-world evidence is applicable across all phases of drug development.

Real-world evidence can help support new indications for existing drugs, because those drugs then

would already be on the market, and real-world evidence can also help demonstrate how a drug

works in populations that weren't studied in the trial or relative to another drug not

included in the study.

There's little doubt that the new sources of data now being open to researchers, clinicians,

and patients hold enormous potential for improving the quality, the safety, and the efficiency

of medical care.

In December 2016, Congress provided CDER with support to continue exploring how real-world

evidence can be integrated into regulatory decision making for new indications for already

approved drugs and to support or satisfy postmarket studies on new drugs.

FDA will work with its stakeholders to produce a framework for a CDER real-world evidence

program and guidance for when and how real-world evidence can be collected and used to support

drug applications.

There is no doubt that this will have a bright future, but the timing when all this will

come to pass is something still unknown.

For more infomation >> FDA CDER Regulatory Science: Real World Evidence - Duration: 3:56.

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TRY NOT TO LAUGH CHALLENGE: Funny Fails Compilation 2017 | Funny Vines Fails & Pranks Compilation - Duration: 10:01.

Thanks for watching

Hope you have a great time

Please, like, comment and subscribe for more!!

For more infomation >> TRY NOT TO LAUGH CHALLENGE: Funny Fails Compilation 2017 | Funny Vines Fails & Pranks Compilation - Duration: 10:01.

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20 New Style Tips On How To Wear Your Turtleneck This Fall - Duration: 3:11.

Wear a long, oversized turtleneck sweater with over-the-knee boots for a very trendy outfit. It might look like you forgot pants, but this is a combo of this year.

Or you can keep the pants and wear your turtleneck tucked into mom jeans. Flat Oxford shoes and glasses are cute ways to keep this updated.

Layering shirts under dresses is a big trend right now. Do it right with a slim turtleneck top and a corduroy, velvet, or suede dress over it.

You can make a short-sleeved duster cardigan even cozier by wearing a turtleneck underneath it.

Wear your slim turtleneck sweater with a suede mini skirt and add a cropped denim jacket. This look is super '90s, but it works for the fashion world right now.

Opt for a cropped turtleneck sweater to do something different. They look killer with high-waist jeans and ankle boots.

Make your midi or maxi skirt work for fall by adding a turtleneck, hat, and ankle boots.

A turtleneck looks perfect under a pinafore style dress like this one. It's preppy and a little schoolgirlish, but it's also really cute.

Go for a more monochrome look by wearing your turtleneck with pants or a skirt in the same shade. Turtlenecks also look great tucked into high waist pants like these.

Wear an oversized turtleneck sweater with skinny jeans and ankle boots with a heel – it keeps the sweater from looking too bummy.

A lot of people opt for turtlenecks in basic colors, like black or gray, but there's no reason you can't stand out. Pick a bright turtleneck sweater, for a real statement piece.

Keep the denim skirt trend going by wearing yours with a striped turtleneck.

Layer an oversized turtleneck over a button down shirt, letting the sleeves and the bottom of the shirt peak out.

You can also layer a slim turtleneck under an oversized sweater, letting just the neck part peak out. This is for those super cold days when you really want to bundle up.

Choose a cropped turtleneck shirt and wear it with high waisted jeans and a cozy cardigan sweater.

A knit turtleneck looks unexpected under a slim leather jacket.

Don't forget about one of the biggest trends this fall! A slim turtleneck looks right at home under a slip dress.

Keep cozy by wearing your turtleneck under a faux fur vest.

Wear an oversized turtleneck sweater with skinny jeans and ankle boots for an easy outfit that also looks really great.

Wear your plaid blanket scarf as a poncho over a cozy turtleneck sweater.

For more infomation >> 20 New Style Tips On How To Wear Your Turtleneck This Fall - Duration: 3:11.

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Wilbert Jones' rape conviction overturned after spending 45 years in prison - Duration: 1:06.

For more infomation >> Wilbert Jones' rape conviction overturned after spending 45 years in prison - Duration: 1:06.

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The Voice Tree - Little Spare Time (Official Music Video) - Duration: 4:03.

We don't need no sleep,

We don't need no beds.

We'll have more time to speak,

And clear out our heads.

As the days turn to weeks,

We'll fall out our seats.

We give up our place,

Carry on into space.

Open up your eyes,

There's always something to lose.

Shed away your disguise,

Wake up, it's time to choose.

Disarm and face your fears,

It will lead you to your fate.

All there is is now and here,

And time doesn't wait.

Time doesn't wait,