Introducing a widget that can be used to "Google Sound Search" of Android from the home screen
Hello everyone
This time, we will introduce a widget that you can use the "Google Sound Search" of Android from the home screen
It is music search in the Android "Google Sound Search" function has been implemented
If you want to use a regular "Google Sound Search" is, we do a search and let the music flowing in the vicinity in the voice search standby state to Android,
Widget is also possible to use that can be called the "Google Sound Search" to direct
Widget of "Google Sound Search", add to the home screen looking for a "Google Sound Search" from the Android widget additional items of
Widget of "Google Sound Search" is "♪" icon
You will be able to launch the "Google Sound Search" directly by touching it
"Google Sound Search" the people that are commonly available, please try by all means to reference
Or more, was the introduction of widgets that can be used to "Google Sound Search" of Android from the home screen
For more infomation >> Introducing a widget that can be used to "Google Sound Search" of Android from the home screen - Duration: 1:31.-------------------------------------------
10 Secrets About The Disney Pixar Universe That Will Blow Your Mind - Duration: 6:31.
Since their first film, Toy Story, Disney Pixar has been amazing audiences and has continued
this for over 20 years but entertainment is only one factor from the Pixar Universe.
The talented filmmakers at Pixar enjoy sneaking in hidden secrets and inside jokes in each
one of their films.
You need to live and breathe Pixar films to know all ten of these because we are not going
to be counting easy secrets like the Pizza Planet Truck or A113 cameos.
Get prepared to have you mind blown and don't forget to subscribe to Screen Rant for more
fun videos like this one.
Here is Screen Rant's list of ten Secrets About the Disney Pixar Universe That Will
Blow Your Mind.
The Incredibles in Ratatouille
The film Ratatouille is laced with Easter Eggs, so much that we all remember when Dug
from UP shows himself but what about The Incredibles Easter egg?
In one scene Linguini has to find a place to hide Remy and he looks for the perfect
spot, before deciding in his toque blanche he has another idea.
That is to place Remy down his pants, once he pulls open his pants he reveals his boxers
with The Incredibles logo plastered all over them.
How many of you spotted those boxers because you almost bought the same pair?
Don't worry, we won't judge.
Finding Nemo in Toy Story 3
You're going to need your pause button for this one.
When Buzz is making his escape from the Caterpillar room of the Sunnyside Daycare in Toy Story
3 he whizzes by on string.
If you pause the scene just right you can see paintings in the background on the window.
Two of these paintings are Dory and Nemo from Finding Nemo, once you know they are there
it is easy to spot the aquatic characters.
Especially with Nemo's orange-and-white-striped colorings.
Luxo Jr. in Wall-E
Planet Earth is covered with so much trash in 2008's WALL-E that humans left an adorable
robot by the name WALL-E there to clean it up.
He has the habit of collecting items he finds interesting and sharing his spoils with his
cockroach friend.
Once a reconnaissance robot, EVE shows up he goes from cleaning mode to impressing mode.
In one scene he makes a statue of EVE and her right arm is made from Luxo, Jr. Pixar's
favorite desk lamp.
Gastows in Cars 2
It seems that almost every Pixar film has an Easter Egg with a Cars vehicle in it and
we will be showing you a hard to find one of those soon.
But what about the Ratatouille nod in Cars 2?
The film takes us on a World Grand Prix tour with stops in England, Japan and Italy.
One destination the crew travels to is Paris France and if you don't blink you might
see Gastows.
Gastows is the vehicular version of Ratatouille's Gusteaus Restaurant, maybe the crew stopped
there for a glass of synthetic oil before the big race.
Monsters, Inc. in Finding Nemo
When we visit the dentist office in Finding Nemo most people spot the Buzz Lightning toy
on the floor in front of the toy chest.
But that's not the only toy there, there is another hidden toy that you can spot if
you turn this dentist office into an optometrist office.
Focus really hard and look in the toy box, there is Boo's teddy bear from Monsters,
Inc.
It's difficult to make out, but once you spot it, that's definitely Boos teddy.
We hope Boo comes back and picks up her teddy bear.
Luxo Jr. in Toy Story 2
Here is one for you astronomy buffs out there.
Have you ever sat under the night sky and try to make out a constellation you were taught
about in science class and wonder how those stars look like a scorpion?
Well, Pixar gave us an easier constellation to find, when Buzz flies back down to earth
in Toy Story 2 look closely at the stars.
There is Luxo Jr. the famous desk lamp of the Pixar short film in constellation form.
Let us know if you spot him in the night sky above your house.
Newt in Brave
Pixar loves to give you sneak peeks in their current films about upcoming films.
Remember when Boo offered her Nemo doll to Scully in Monsters, Inc. two years before
Finding Nemo even hit theaters?
In the film Brave, the witch holds a newt up when concocting a spell to foreshadow the
upcoming film, Newt that Pixar was working on.
Did you miss this Easter egg or what about the film Newt?
You probably did because this Newt was shelved and was never made, but all you true Pixar
fans already knew this.
Right?
Cars in Toy Story 3
Be prepared for not one but three hidden Cars references in 2010's Toy Story 3.
In the previous Toy Story film Andy had a calendar with A Bug's Life reference on
it but since he's grown up now we see the image is now of Snot Rod from Cars.
Then when we head into the Sunnyside Daycare, one child can be seen sporting a 95 t-shirt
with a lightning bolt design.
That same lightning bolt and red color can be seen on a wooden car in the background
of the same location.
Did you spot any more Cars references we missed?
Luxo Jr. Ball in Up
The small yellow ball with a blue stripe and red star was first featured in an early Pixar
short by the name of Luxo, Jr.
Buzz uses it to help fly in the first Toy Story film and has shown up in a lot of other
Pixar films.
One that people usually miss in in the 2009 film Up because they are paying attention
to the antagonist of Toy Story 3, Lots-o'-Huggin' Bear.
Look to the right and you can see the Luxo Jr. ball right in front of the little girl.
Whoever is the manufacturer of this ball is probably a millionaire now.
The Incredibles in Finding Nemo
In 2003's Finding Nemo a boy is seen sitting near his mother reading a comic book as he
waits to be seen by the dentist.
Nothing looks too peculiar in this scene but check out that comic book.
It's a retro design for a golden age, pre-red-suit Mr. Incredible.
We wonder if Edna Mode had any say in his outfit, obviously one capped crusader shown
on the comic wasn't dressed by Edna because we all know how she feels capes.
There you have it ten secrets about the Disney Pixar universe that will blow your mind.
Don't forget to subscribe to Screen Rant for more fun videos.
Thanks for watching.
-------------------------------------------
Beetches - Duration: 1:53.
♪
[male narrator] Based on the movie Beaches and the Lifetime movie Beaches.
[record scratch] Okay enough.
- Get out. You're done. - Hello. Your pictures are outside.
Oh my God, we're such Beetches.
♪
[male narrator] Beetches.
That's gonna be me one day.
You're were the best dancer at my quinceañera.
Trick or treat!
All of my hard work has finally paid off!
I'm officially a manager at Sephora.
[female] Beetch, I'm gonna be a dancer in a Wale video.
♪
I was horrible!
Beetch, maybe you're not supposed to be an actress.
Not everybody's good at everything. Remember Gigli?
[female] Wait, what do you mean you went on a date with Wale?
- You know how much I love him. - How could I resist?
He's super cool and he's best friends with Jerry Seinfeld.
I love Jerry Seinfeld too.
Beetch, you said you didn't even understand that show.
[female] You caught Angel with another woman at [indistinct location]
and now you're gonna have this baby by yourself?
- Yeah. - No bro!
You're gonna have this baby with me, and we're gonna go kick Angelo's ass!
Okay.
[male narrator] In a very diverse motion picture
about relationships about la vida.
Where's my mom Beetch?
She died. I'm your mom now Beetch.
[male narrator] Once in a vida time you make an amiga-ship
that lasts for siempre.
♪
-------------------------------------------
KSBW Pet of the Week: Meet Reese the Pup - Duration: 1:58.
ART: TIME FOR PET OF THE WEEK.
GOOD AFTERNOON.
IT WAS THIS ADORABLE?
>> THIS IS REESE.
HE'S IN A LEGAL PUPPY.
SHE CAME TO US AS PART OF AN
UNWANTED LITTER.
THERE ARE FOUR OF THEM TOTAL.
TWO WITH FUZZY HERE LIKE HER AND
TWO WE SHORT HAIR.
THEY ARE ALL AVAILABLE FOR
ADOPTION AT THE SPCA.
VERY, VERY SWEET.
ART: BEAUTIFUL HAIR.
IS IT REECE BECAUSE IT LOOKS
LIKE A PEANUT BUTTER CUP?
>> THE WHOLE LITTER HAS R NAMES.
AFTER ALL THIS RAINFALL, AND
EVEN SUPER BUSY.
>> WE SEE STRAIGHT ANIMALS COME
IN.
AVC, GIVE US A CALL.
ART: IF YOU WERE TO GET SPAYED
AND NEUTERED, DO YOU HAVE
ANYTHING GOING ON?
>> SHE IS READY TO GO.
IT'S ALL INCLUSIVE.
IF YOU NEED TO GET SPAYED OR
NEUTERED, WE HAVE GREAT DEALS ON
THAT.
RIGHT NOW FEMALE CATS ARE ONLY
$20 AND MALE CATS ARE $10.
IT WOULD DO A LOT OF GOOD FOR
THE COMMUNITY.
ART: I SEE THE CREWS BACK THERE.
BACK ON THE WEBSITE PERHAPS?
>> IT'S AT THE WEBSITE.
ART: HOW MANY IN THIS LETTER?
>> THERE WERE FOUR OF THEM.
THEY ARE ALL AVAILABLE RIGHT
NOW.
IF YOU LOOK ON THE WEBSITE, YOU
WILL SEE ALL THE PICTURES AND
THE READY TO GO.
COME BY AND VISIT US.
ART: SPCA FOR MINOR COUNTY. --
MONTEREY COUNTY.
YOU CAN GET A HOLD OF THEM AND
FIND OUT IF REECE AND HER
-------------------------------------------
Group protests outside Sen. Collins' Lewiston office - Duration: 0:44.
MARC GONZALEZ, ABC NEWS, NEW
YORK.
TRACY: HERE IN MAINE, MORE THAN
A DOZEN PEOPLE PROTESTING
OUTSIDE SENATOR SUSAN COIN'S
LEWISTON OFFICE TODAY.
READ "TRUMP APPOINTING FOXES T
GUARD THE HEN HOUSE."
THE GROUP SAYS THEY'RE UNHAPPY
WITH PRESIDENT TRUMP'S
DISIONS, FROM THE AFFORDABLE
CARE ACT TO HIS CABINET NOMINEES
AND THEY WANT COLLINS TO DO
SOMETHING ABOUT IT.
>> SUSAN COLLINS STEPPED UP TO
THE PLATE, BUT SHE DID ONLY
AFTER SHE SAW ALL OF THE
PROTESTS
ONLY IN RESPONSE TO THE PSSURE
SHE WAS FEELIN
TRACY: SENATOR COLLINS WAS NOT
AT THE LEWISTON OFFICE.
ONE OF HER STAFFERS LD T
PROTESTORS TO LEAVE THEIR
-------------------------------------------
thomasville fire - Duration: 1:47.
BETHANY: SOME MAY LOOK AT THIS
AND ONLY SEE DESTRUCTION, BUT
DANIEL WOOD AND HIS FAMILY SEE A
MIRACLE.
>> I GUARANTEE IF I WOULD HAVE
PANICKED, YOU WOULDN'T BE
GETTING THIS INTERVIEW RIGHT
NOW.
THAT'S HOW FAST IT WENT UP.
BETHANY: DANIEL SAID THEY HAD
JUST PUT THE BABY DOWN LAST
NIGHT WHEN THEY HEARD AN
EXPLOSION.
>> I SAW A FLASH AND
IMPROVEMENT.
BETHANY: HE WALKED OUT TO FIND
HIS STAIRS ON FIRE.
>> THAT'S MY ONE WAY IN AND MY
ONE WAY OUT.
IF THAT GOES UP, WE'RE GOING TO
HAVE TO JUMP OUT THE WINDOW.
BETHANY: HE THEN WENT INTO HIS
KIDS' ROOM GRABBED THEM BOTH AND
RAN THROUGH THE FLAMES
>> I CUT OUT AND WENT STRAIGHT
TO THE KITCHEN AND TO THE FRONT
DOOR.
IT WAS ONLY A MATTER OF SECONDS.
BETHANY: DANIEL, HIS WIFE, AND 3
KIDS ALL MADE IT OUT WITH ONLY
SCRATCHES AND BRUISES.
BUT THERE WAS SOMETHING THAT WAS
WAS LEFT BEHIND.
>> BY THE TIME I GOT MY FAMILY
OUT, I COULDN'T GO BACK IN.
I MEAN THE WAY IN WAS ALREADY IN
FLAMES, MY FRONT DOOR, AND I
COULDN'T SAVE MY DOG.
BETHANY: IT'S A GUILT DANIEL'S
STRUGGLING WITH.
>> THAT WAS A LOYAL DOG.
HE WOULD HAVE DRUG ME OUT.
BETHANY: BUT IN THE END HE'S
THANKFUL AT LEAST HE AND HIS
FAMILY MADE IT OUT ALIVE.
>> JUST VERY THANKFUL.
PRAISE THE LORD THAT I STILL GOT
MY FAMILY.
REALLY MAKES YOU APPRECIATE
LIFE.
-------------------------------------------
PANESCONE - An Italian Panettone Inspired Scone - Duration: 6:53.
Hi and a huge welcome to Steve's kitchen.
We are here in Italy, actually in Sicily
to be precise and we had a great
Christmas i ate lots of Panettone over
Christmas they are delicious we even
baked one or two and I haven't had
chance to make the video but I can tell
you now a good panettone takes time to
make, so what I wanted to do was share
back to my Italian friends here a fusion,
something that comes from my side of
cooking which still has all the flavors
of Panettone and I hope you like it.
We've already seen from the title it's
called a Panescone and it's got all the
goodness of an English scone with all
the flavors and essences of a good
Italian Panettone but on a plus side you
can make these in 30 minutes from start
to finish.
Now just for fun I made these little
baking paper collars, so we're going to
have the Panettone look and you don't
have to make these but I want to
encourage my scones just to rise up
rather than spread out. To make the
papers you want a 11 or 12 inch piece
of baking paper, that's around about four
inches just a little bit over four
inches, I've folded that in half and we're
just going to tuck that in and pull it
into a collar and the size will very much
depend on the cutter you use, we're using
a glass today so I've measured it
roughly the diameter of the glass and
very close to the seam, we're just going
to staple it closed top and bottom so
we've got a nice little collar and it is
optional of course, you're still going to
get that lovely Panettone flavor even if
you don't have the collars. If you're wondering
what's cooking in the background here, a
lot going on the kitchen Heinz style
baked beans going on here and we've also
got a series a bread baking series that
were filming so look out for that the
channel later on. I've got myself 450
grams about a pound of all-purpose flour
or double-zero flour in this case, get
that into our mixing bowl and I'm going to
add a couple of teaspoons of baking
powder in with that and about
three-quarters of a teaspoon of salt and
quickly I just weighed out a hundred and
fifty grams that's five ounces of butter. Now
this butter is a little bit soft which is
perfect and Im just going to cut it up
and pop
in with my flour, there's about twenty
percent more butter than I would
normally use for scones but I want that
buttery flavor you get with a Panettone.
The next thing we're going to do is just
lift the butter, rubbing the butter and
the flour together. So you can see after
just a minute or so we've got this
lovely breadcrumb consistency. Now you
could do this in a food processor but be
careful you don't want to overwork it
otherwise you'll end up with a tough dough
Time to Panescone this up a little bit,
we've got one lemon and one orange I'm
just going to use the zest of these
beautiful Sicilian lemon I want to get
all of the zest off of this and also
the zest off of one orange zest, it has all
those beautiful aromatic oils in there
so we're not getting any bitterness, just
all the flavor.
Now I'm using my homemade candied peel.
I've got a hundred and twenty grams that's four
ounces
add that to my mix, A hundred and twenty
grams thats four ounces of sultanas and 120
grams thats four ounces of granulated sugar.
Now we just give this a nice thorough
mix through and we need to bind this
mixture together so I'm using full cream
milk. I've got about a cup of milk, pop
that in there, just going to use a fork
to start to pull this together and then
I'm going to take my hands in there and
this should be quite a dry mixture, so I
pull that together and we've still got a
nice loose dough like that but what we're
going to do is move this now onto my
counter. Now I want a little bit of flour
on the counter
we don't need a rolling pin for this by
the way, what we're going to do is shape our
dough out and we're going for a thicker than
normal scone so I'm looking for
something that's about almost an inch
and a half in height. Now I haven't got my
cutters with me so I'm using the bottom
of a glass and to cut my scones I just
want to get the glass into some flour.
Now bring it over to my dough and we're
just going to cut me through
and the flour will let the little scone
come out like that.
Now I'm going to put my an Panettone papers
on there, going to take my little scone
and just drop it in the center of the
paper like that and hopefully when that
bakes it will rise a little bit and
it'll form itself around the paper. I'm
going to cut out half a dozen of these,
got another little paper, then I'm just
going to drop this go into the centre,
give it a little shake-up. Now we made
nine mini Panescone here, I've preheated my
oven, it's a fairly hot oven to 200
degrees Celsius that's 400 Farenheit and
we're going to bake these for about 15
minutes might be a tiny little bit
longer, we don't want to let them go too dark, we do
want them to cook all the way through.
Now look at those they smell delicious
just like panettone, they come very near
to the top so I could have probably made
the collars a little bit smaller.
What I need to do now is let these
completely cool down before we serve
them. Now I've started to unwrap some of
these, come in a little closer and just
take a look at these, look how gorgeous
that little Panescone looks. Now I'm
just going to dust them over with a little
powdered sugar.
Now I've got this little runt one at the
back here but I still think he looks
fantastic I'm just going to take the
collar off of that there's my little
Panescone, the smell coming from these
is just absolutely delicious it reminds
me so much of the Panettone we had over
the Christmas period. Like any good scone they should be light and crumbly
you should be just able to pull them
apart like this and inside you'll have a
lovely crumb and smell the citrusy smell
in there is delightful. I'm going to give
this a try, I want you to try this at
home and comment down below and let me
know what you think.
As they should be
it's still just a little bit warm and it's
so delicious, break these open, a little
bit of fresh butter maybe some cream
some nice marmalade or jam.
I hope Italy will forgive me for
playing with their traditional recipe these are really good though unlike
Panettone though these just take 30
minutes from start to finish so you can
serve them to your guests at short notice. If you
decide to make them let me know what you
think, Share some pictures across on social
media, share the love, give this video a
thumbs up and I will see you very
shortly, take care.
-------------------------------------------
Bagna alla vaniglia - Duration: 2:58.
For more infomation >> Bagna alla vaniglia - Duration: 2:58. -------------------------------------------
fuckin sora on world of final fantasy?!?!?! - Duration: 20:17.
Yo, what's up guys and welcome back to world of final fantasy.
I told you I would only do Kingdom Hearts 2.8 for this week, but I will let this sneak in somewhere cause..
the original square enix youtube channel uploaded a video, that new dlc is there for this game.. and it was SORA!
and I will get this now!
so uhm
uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh
I will watch the video to know how to get sora!
alright I've watched it and I have to go into the playstation store.
uhm.. pff where is it?
no? mh alright.
I will check it again how it'll work.
gues I found it now.
I just clicked the analogue stick to the right side at the search. didn't know that this works but ok.
uhm.. yeah.
and now I should show him to you.
hopefully I am not somewhere random.
cause I have to back then. this would be bad.
but I can imagine where I've stopped.
yup, and I have to go back.
ok so I have activated this switch so a door somewhere opened and I got this timer now.
well it's a bit spoiler, but..
I will show you how I will get back. or maybe further? idk.
the stupid thing is that the time runs WHILE I AM SAVING
but no problem.
oh perfect!
are you kidding me?
now I can't leave or what?
ohh! yeah.
oh alright I am almost out.
uhm...
alright there we go
oh god, it seems like I really have to spoiler you.
well.
can I activate this? nope but I can go in there. down there is.. nothing.
oh so if someone speculates who the fuck this guy is who is sitting on top of my rock guy..
that's my sparky who evolved. well it's called metamorphosis not evolve.
this should be it, right?
wait.. first.
wow
alright i gues i have to go into the girl.. I mean into the room of the nameless girl.
but It could be that he is already in my options since I have downloaded him anyways.
but this might be not the case. I probably have to do a mission first.
mhh.. ok it should be at hero emblems.
no, I don't have him. that means he is still at the room of the nameless girl.
and I have to unlock him
oh well.
this part doesn't have to be too long
in case there is no boss fight I mean..
that's all sparkys.
no it's that guy from kingdom hearts.
this joke was so bad but ok xD
argh
and now I am doing thunderstrike on that thunder guys..
oh that's not even not effective.
uhm.. let's use this on reynn.
oh, there is only one left anyways.
oh, I can catch him.
ah comon! he let my ball explode. wtf dude.
what are they doing now? some kind of ritual or what?
this guy is just praying for a bit.
please. don't come up with a boss fight. I just wanna show you sora...
and there it is, a boss fight, right?
ok nevermind, right?
can I go back now?
ok a gate has opened. let's go
through the gate right away.
alright, ok.
I don't know if I've showed you the room of the nameless girl (i haven't u.u) but it's basically a room where you can do your hero emblems from the people you meet.
I can't chose sora..
this is with vivi and that's with enna.
did I missread and have to go to the colloseum?
let's just check that one out.
you will see the coloseum too really soon. gues 2 or 3 parts.
but I'm not sure.
but at saturday (last saturday) I've played this game pretty much a whole day.
I did even more parts then in the new Kingdom Hearts.
oh wait. another guy is standing there.
what does he want?
ok that's online mode.
let's see if sora stands in that.
nope-
ok just a moment please.
another of these wanna be jokes and I'll kill ya!
alright so I've clicked on this once again and read everything.
I have to be able to summon the ability redeemer.
so I will get sora if i got this ability. so sora is on the disk but I can't use him for now. oh well.
well you will see it if i got this ability.
anyways, sorry that I couldn't show you sora. I will add the link into the description that you can see how it looks. and as I said, hope you've enjoyed and hope to see you again, next time!
-------------------------------------------
#AbrahamHicks ~ The simple key to feel good - brilliant conversation ♦ Esther Hicks #LawofAttraction - Duration: 14:52.
For more infomation >> #AbrahamHicks ~ The simple key to feel good - brilliant conversation ♦ Esther Hicks #LawofAttraction - Duration: 14:52. -------------------------------------------
Alkaline 2017 Mix - Alkaline Hot Inna Di War Mixtape Featuring Tommy Lee,Masicka,Aidonia,Popcaan - Duration: 27:53.
BADDEST ALKALINE CLASH EVER !!!
-------------------------------------------
Is Gemini 2 a Scam? You Won't Believe It! - Duration: 1:40.
Is Gemini 2 a Scam?
Hi, I'm Gary Horton, Founder of ScamAvenger.com.
Thanks for joining me Gemini 2 or Gemini 2 Reloaded, is promoted
on the Gemini-Reloaded.com website as the brain child of Brandon Lewis.
In the sales video, Lewis claims his software generates more than $12,000 each day.
Unfortunately, Brandon Lewis is an actor, and the Gemini 2 software is worse than fake.
It's dangerous.
The Gemini 2 sales video is trying to trick you into opening a binary options trading
account with an unregistered broker.
The United States Securities Exchange Commission (SEC) warns that unregistered brokers can
steal people's money, steal identities and manipulate software to make losing trades.
There is no magic software that will make you rich.
If you are searching for a legitimate way to earn an income online, my friends and I
will help you for free.
We're a community of online entrepreneurs who help people build thriving online businesses
based on their hobbies and passions.
We would be delighted to help you.
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I'm Gary Horton, and I'm here for you!
-------------------------------------------
E-Commerce Manager & B2B Websites | Ted Sellers | Minneapolis, Minnesota | Ecommerce sales - Duration: 1:18.
E-Commerce Manager & B2B Websites
E-Commerce Manager & B2B Websites
E-Commerce Manager & B2B Websites
E-Commerce Manager
-------------------------------------------
Prader-Willi syndrome - Prader-Willi syndrome causes, symptoms - Duration: 3:08.
What is Prader-Willi syndrome?
PWS is a complex genetic disorder affecting appetite, growth, metabolism, cognitive function
and behavior.
It is typically characterized by low muscle tone, short stature (when not treated with
growth hormone), incomplete sexual development, cognitive disabilities, behavioral problems,
and the hallmark characteristics – chronic feelings of insatiable hunger and a slowed
metabolism that can lead to excessive eating and life-threatening obesity.
Those who have PWS need intervention and strict external controls, sometimes including padlocking
access to food, to maintain normal weight and to help save their lives.
How many people have Prader-Willi syndrome?
It is estimated that one in 12,000 to 15,000 people has PWS.
Although considered a "rare" disorder, PWS is one of the most common conditions seen
in genetic clinics and is the most common genetic cause of obesity that has been identified
to date.
PWS is found in people of both sexes and in all races worldwide.
Why does Prader-Willi syndrome occur?
Most cases of PWS are attributed to a spontaneous genetic error that occurs at or near the time
of conception for unknown reasons.
In a very small percentage of cases (2 percent or less), a genetic mutation that does not
affect the parent is passed on to the child, and in these families, more than one child
may be affected.
A PWS-like disorder can also be acquired after birth if the hypothalamus portion of the brain
becomes damaged through injury or surgery.
What is the cause of Prader-Willi syndrome?
Basically, the occurrence of PWS is due to lack of several genes on one of an individual's
two chromosome 15's – the one normally contributed by the father.
In the majority of cases, there is a deletion – the critical genes are somehow lost from
the chromosome.
In some of the remaining cases, the entire chromosome from the father is missing and
there are instead two chromosome 15's from the mother (uniparental disomy).
The critical paternal genes lacking in people with PWS have a role in the regulation of
appetite.
This is an area of active research in a number of laboratories around the world, since understanding
this defect may be very helpful not only to those with PWS, but to understanding obesity
in otherwise normal people.
People with PWS have a flaw in the hypothalamus part of their brain, which normally registers
feelings of hunger and satiety.
While the problem is not yet fully understood, it is apparent that people with this flaw
never feel full; they have a continuous urge to eat that they cannot learn to control.
To compound this problem, people with PWS need less food than their peers without the
syndrome because their bodies have less muscle and tend to burn fewer calories.
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