This past Friday Donald Trump decided to jump into the fray trying to defend his supreme
court nominee Brett Kavanaugh.
And he did it the only way he knows how, to get on Twitter and start attacking the woman
accusing Kavanaugh of sexual misconduct, Dr Christine Ford.
His Tweets were so bad and so damaging for his own nominee and the Republican Party that
Senate Majority Leader, Mitch McConnell had to get on the phone with Donald Trump, according
to reports, that afternoon and say, "Please stop tweeting about this because you're making
the situation so much worse."
Mitch McConnell, the man without a backbone, a spineless republican suck up actually decided
to get on the phone and say, "You're making things worse.
Could you please stop?"
Now, trump sent out several tweets about Dr Christine Ford, the woman accusing Kavanaugh
of sexual misconduct, but I'm just gonna read one.
This is the most disgusting.
It is, "I have no doubt that if the attack on Dr Ford was as bad as she says, charges
would have been immediately filed with local law enforcement authorities by either her
or her loving parents.
I ask that she bring those filings forward so that we can learn date, time and place."
Now, the reason that's so disgusting is because he's trying to play it both ways and make
it sound like, "I'm not saying if she ... I mean, if she has those bring them forward
and we'll evaluate them."
But he's also saying, "If it had happened she would have filed a report and she didn't,
so obviously it didn't happen."
He is sitting there, as he has done so many times, including with the 19 plus woman who
have credibly accused him of sexual misconduct, trying to act like it's a lie.
But he's trying to do it a little more diplomatically than usual, which also leads me to believe
that maybe Trump himself isn't the one who tweeted this out.
Nonetheless, Mitch McConnell had to get on the phone and say, "Could you please not say
these things.
We're already between a rock and hard place here.
We don't need you making it worse."
Well guess what Mitch, Donald Trump was literally saying the exact same thing that the rest
of your republicans on the senate judiciary committee have already been saying.
Lindsay Graham said that it doesn't matter what Dr Ford testifies and says during her
hearing.
It's not gonna change his vote.
I mean, your own buddy Lindsay Graham said, "No matter what she says, I don't care.
I'm still voting to confirm him."
Other republicans have said, "This is obviously a democratic plot.
This didn't really happen.
They're wasting our time."
And you're just only mad at Trump?
You're not standing up to anybody.
You're standing up to the one guy that you don't have to deal with on a daily basis.
How about you go tell the other republicans on the judiciary committee that what they're
saying about this woman and these accusations is absolutely insane, and they need to shut
their damn mouths until she is allowed to come in and give her testimony.
Or better yet, tell them to shut their mouths until after we get an FBI investigation into
this thing.
You can't just find one guy who works in a different building, Donald Trump, and say,
"Oh, you got me so mad.
I'm gonna ... I'm gonna stand up to you.
Could you stop making things worse," and then ignore the guys working down the hall from
you who are making things so much worse for you.
See, Mitch, you thought this was gonna be a winning issue.
You thought this was gonna help you in the midterms by being able to go voters and say,
"Look, republicans gave you two Supreme Court nominees in a year and a half, that's remarkable."
But instead, you failed.
And we know, according to reports for the last year and a half, that you've been working
with the Federalist's Society to feed these nominees to Donald Trump.
So, yeah.
Brett Kavanaugh's failure is your failure.
If you wanna be mad at somebody about all the horrible things republicans are saying
right now, you need to start with yourself because everything that happens from this
point forward, with regards to Kavanaugh, is 100% on you Mitch.
You did this.
You live with it.
For more infomation >> Mitch McConnell SCOLDS Trump Over His Kavanaugh Tweets - Duration: 4:13.-------------------------------------------
Protein Structure and Folding - Duration: 7:46.
We all have things that challenge us- and for me- it is folding.
Sheets, towels, shirts- let's just say I invest in a lot of anti-wrinkle laundry spray.
Amazing invention.
My issue with folding extends to paper too.
I know foldables in the classroom can be a powerful way to organize concepts, but for
me, it was the actual folding part that I tended to get stuck on.
You may think of folding as a convenience- of a way to take something and make it more
organized or condensed so it doesn't have to take up as much space.
This is true.
But in biology, folding can also have a lot to do with function.
We've mentioned how amazing proteins are.
They can play so many roles.
They can make up channels, be a part of structure, serve as enzymes for important biological
processes, be involved with protecting the body...just to name a few.
We've also mentioned that you are making proteins, all the time, in a process known
as protein synthesis.
But the conclusion of producing a long chain of amino acids doesn't necessarily equal
a functional protein.
There are modifications to a protein that often need to happen in order for it to be
functional.
By modifications, we can mean many things.
It might be adding certain chemical groups, such as phosphorylation---something to definitely
explore.
But another important event to make a functional protein is---believe it or not---folding.
But before we get into protein folding, let's talk about shape and why shape is so important.
Shape and function, in biology, frequently go hand in hand.
In our cell signaling video, we mention how protein receptors and the signal molecules
that bind them can fit together so perfectly to start some type of cellular response.
Or in our enzyme video, we talk about how enzymes---which are frequently proteins---have
a very specific shape for the substrates that they build up or break down.
When we talk about the way proteins are folded, we need to understand the different levels
of protein structure because there are different ways of folding that can happen in the different
structural levels.
The first level of protein structure is primary structure.
This is the sequence of amino acids that make up a protein.
Amino acids are the monomer---which means the building block---of a protein.
They are held together by peptide bonds.
In protein synthesis, amino acids are added to form a polypeptide chain and proteins are
made of 1 or more of these polypeptide chains.
Genes, which are made of DNA, determine the order and number of these amino acids.
That sequence is critical to the protein's structure and function.
In our mutations video, we talk about how one amino acid can be changed in sickle cell
disease.
Even a single change of an amino acid has the potential to affect a protein's function.
We do want to point out- each amino acid has a carboxyl group, an amino group, and a R
group- an R group is also called a side chain.
So even though we have them drawn here like a chain of circles, realize that each of those
circles we're drawing is an amino acid like this.
Next, we move on to secondary structure.
Folding is really going to start to happen.
In secondary structure, the sequence of amino acids that we mentioned in primary structure,
can fold in different ways.
The most common ways are the alpha helix and the beta pleated sheet and which one of these
foldings the protein does depends on the amino acid arrangement it has.
Both of these shapes are due largely in part to hydrogen bonds.
Those hydrogen bonds can occur at specific areas of the protein's amino acids.
Specifically, these are hydrogen bonds involving the backbone of the amino acid structure-
we're not focusing on the R groups right now.
On to tertiary structure.
This is looking at more folding that occurs in the 3D shape of a functional protein.
And a lot of this is due to something we haven't mentioned much…the R groups.
Also called side chains.
See, the amino group and the carboxyl group are generally standard parts of an amino acid,
although the R group found in amino acids can vary among different amino acids.
That means, the R group can define the amino acid and can make amino acid behave a certain
way.
For example, some R groups are hydrophilic.
They like water.
Some R groups are hydrophobic.
They don't.
And remember that proteins contain many amino acids which can contain different R groups
and so different areas of the protein can therefore be impacted based on those R groups.
When protein folding is going on, amino acids with hydrophilic R groups may hang out on
the outside while hydrophobic R groups.
Where are they?
They may hang out in the inside part of the protein.
The 3D shape is due to other interactions besides hydrophobic interactions.
Ionic bonds, Van der Waals interactions, disulfide bonds, and hydrogen bonds- all involving the
R groups- also influence the folding occurring in tertiary structure.
Something to explore.
Now when we've been talking about a protein, we've been talking about a polypeptide chain
that has been folded into a functional protein.
But proteins can be made of 1 or more polypeptide chains and in quaternary structure---you are
looking at a protein consisting of more than 1 polypetide chain.
Each of these polypeptide chains can be a subunit and interactions between them such
as hydrogen bonds or disulfide bonds can keep them together.
Going back to the folding, I know what you might be thinking.
Who is doing this folding anyway?
Are the proteins just folding themselves?
Well, the interactions mentioned like hydrogen bonds and R group interactions are occurring
depending on the protein's own amino acids.
One reason why amino acid sequences are very important for protein function.
But folding is far more complex than that, and there can be intermediate steps involved
when a protein is folding.
In fact, there's a phrase you can search called the protein-folding problem to learn
more about the questions scientists continue to explore regarding protein folding.
Research has shown that proteins often have help in the folding process.
Chaperonins, for example, are proteins that can help with the folding process.
They have almost a barrel shape.
Proteins go into them, and the chaperonin tends to have an environment that is ideal
for the proteins' folding.
This can help the protein to be folded correctly so it's functional.
Just wish I had something like that for my towels.
All of these interactions we mentioned in primary, secondary, tertiary, and quaternary
structure are paramount for a mature protein to have its correct shape so it can carry
out its function.
And that's very relevant!
There are many diseases that are related to protein misfoldings.
Check out some of our further reading suggestions in the description about that.
One last thing we haven't mentioned: each protein has an ideal environment for functioning
which might include a certain temperature or pH range.
If the protein is exposed to something outside of its ideal temperature or pH range- exposed
to high heat for example- you can disrupt the interactions that we have talked about
taking place at the different structural levels.
This can denature the protein, which disrupts its shape.
This prevents it from functioning correctly.
And depending on what caused it to be denatured, sometimes you are interfering with many levels
of protein structure.
Sometimes, it's just one or two levels.
Sometimes denaturing a protein may be reversible.
But in many other cases…it's not.
The environment that a protein is in definitely matters for its functioning.
Well, that's it for the amoeba sisters, and we remind you to stay curious!
-------------------------------------------
Perro muere ahogado en inundaciones en México | Al Rojo Vivo | Telemundo - Duration: 0:32.
For more infomation >> Perro muere ahogado en inundaciones en México | Al Rojo Vivo | Telemundo - Duration: 0:32. -------------------------------------------
Sicarios asesinan a un periodista frente a su casa | Al Rojo Vivo | Telemundo - Duration: 0:33.
For more infomation >> Sicarios asesinan a un periodista frente a su casa | Al Rojo Vivo | Telemundo - Duration: 0:33. -------------------------------------------
Dallas queda bajo el agua con fuertes inundaciones | Al Rojo Vivo | Telemundo - Duration: 0:36.
For more infomation >> Dallas queda bajo el agua con fuertes inundaciones | Al Rojo Vivo | Telemundo - Duration: 0:36. -------------------------------------------
Niño de 12 años acuchilló a su hermano | Al Rojo Vivo | Telemundo - Duration: 0:34.
For more infomation >> Niño de 12 años acuchilló a su hermano | Al Rojo Vivo | Telemundo - Duration: 0:34. -------------------------------------------
Pareja golpeó brutalmente a humilde vendedor ambulante | Al Rojo Vivo | Telemundo - Duration: 0:40.
For more infomation >> Pareja golpeó brutalmente a humilde vendedor ambulante | Al Rojo Vivo | Telemundo - Duration: 0:40. -------------------------------------------
Fuerte tormenta provocó severas inundaciones en Michoacán | Al Rojo Vivo | Telemundo - Duration: 2:14.
For more infomation >> Fuerte tormenta provocó severas inundaciones en Michoacán | Al Rojo Vivo | Telemundo - Duration: 2:14. -------------------------------------------
Juez nominado a la Corte Suprema de EE.UU en problemas | Al Rojo Vivo | Telemundo - Duration: 0:49.
For more infomation >> Juez nominado a la Corte Suprema de EE.UU en problemas | Al Rojo Vivo | Telemundo - Duration: 0:49. -------------------------------------------
Adolescente en Nicaragua murió en medio de protestas | Al Rojo Vivo | Telemundo - Duration: 1:59.
For more infomation >> Adolescente en Nicaragua murió en medio de protestas | Al Rojo Vivo | Telemundo - Duration: 1:59. -------------------------------------------
Hinchas descontrolados desataron guerra callejera | Al Rojo Vivo | Telemundo - Duration: 2:51.
For more infomation >> Hinchas descontrolados desataron guerra callejera | Al Rojo Vivo | Telemundo - Duration: 2:51. -------------------------------------------
♪ "É COMPLICADO..."♫ - Música Original The Kira Justice - Duration: 1:48.
For more infomation >> ♪ "É COMPLICADO..."♫ - Música Original The Kira Justice - Duration: 1:48. -------------------------------------------
VENUM BUILD FOR KODI 17.6 KRYPTON BEST KODI BUILDS AND BEST ADDONS FROM STAR-TEC WIZARD - Duration: 15:16.
What's up guys it's Everything Kodi back with another video
so many of you are looking for a build with lot of different add-ons
and lot of different sources for content then you might want to check the venum build kodi
I've also tested on my fire TV and two other fire sticks the build works great
You will enjoy this kodi build on your amazon fire stick or nvidia shield or android tv box
now I'm gonna give you guys an overview of what it has to offer
offer if you like it I can show you how you can get it installed on your device.
Now if you haven't already go ahead and hit the subscribe button
and make sure you click the little bell icon right next to subscribe so you don't miss any of my posts
so let's go ahead and jump into the overview of the build.
Now once you install it the first section you're gonna run into is the movies section
so you have the widget here at the top
you can scroll through find a movie and tv shows you like.
Don't forget to subscribe and click the bell icon to stay informed.
-------------------------------------------
FULLY LOADED & BEST KODI BUILD 🔥 KODI 17.6 SEPTEMBER 2018 🔥 DUREX KODI BUILD 🔥 DUREX WIZARD - Duration: 16:01.
Hello guys, this is kodi best build back with you again with another video
I wish you doing well having a great time with your friends with family or
Anyone in this video?
We're gonna install a great build working well for kodi krypton any version 17
So now forget to subscribe to my channel and join me in the social media links as you can see right here down
So to get this great build
go right here to settings and press on it and
here, press on the system settings and
Then scroll down to addons and here press on the unknown sources
So press. Yes, and that way you allow to install
any
External sources into your kodi. So right here, press on file manager as
You can see if your kodi is new. You don't have anything install it to kodi
You will get profile directory and add source
If you use to install builds and things you will gather your files right here. So double press on add source
press on done
And right here just copy and paste the source from my website to not miss anything
So its directs Kodi build
Press ok, here. We can name it wizard or Durex or your name or whatever press on ok, so
Here we got it press back
Back one more time to the home page of Kodi. Not the home page of your page of your device
So press on add-ons
and right here, press on this little box as you can see in the top and
He'll press uninstall from zip file. So
choose your file and
Here, we got it you get the plug-in program the Dericks wizard click on it
So it's gonna be install it into your kodi
So it's really amazing build it has a lot of things
So it's one of the top five Kodi builds ever had you get the Xenon Kodi build
It's also amazing got the D Rex you got
no limits you get a
Lot of great builds you can get to install into your box
So right here once its install it you get it
Right here on your program arrows as you can see you got the directs wizard install it to your Kodi
Click on it to open it
So right here will get builds you get maintenance you get add-on installer
You got save data and contact present builds
You got only one single build but you got different servers
You got the server 1 2 3 & 4 5 servers
So right here press on the first server
Is the version 9.0?
So right here you get the fresh install and the standard install
The fresh installed if you get a previous build already install it to your Kodi
They got a lot of damage it files. You got a lot of problems do a fresh install
So the standard install if you don't have anything install it yet to your fire TV
or show you to your Nvidia shield or any Android box, press on the standard installed as
You can see right here
it's a super-fast built especially for fire TV sticks and
Loaded with the top Kodi add-ons as you can see it written in the corner right here
So press on. Yes installed
So he'll get the download process going
So don't forget guys to like the video share it with your friends and family and leave me your comment in the comment
Section and say happy birthday to me. Happy birthday. It's my birthday today
I can't wait to celebrate it with my family
So here we get
You got the download process going. I'm gonna back after everything is done, right?
So right here as you can see you get the download process done and now it's installing your files into your box
So just be patient and wait, don't press right here on cancel or press on this empty space
Hold on and wait some seconds until you get everything done, right?
And
Then you can first close Kodi
Restart it again, and you will get this great amazing
cloud rebuild install that
So right here it's done and
Now press on first close Cody and restart it again to get this amazing built install it into your box
So I got a lot of questions people asking me I pressed on first close Cody
But when I restart Cody I didn't get the skin
So I'm gonna show you how to do that if the skin doesn't load
With you into your box, so press on first close Cody and restart it again
So once you install the build or repress on first close Cody
You got the home page like this if you don't get it
You did everything and you didn't get this home page press on system right here
So you got the normal skin of Cody like this you got it
This tre is the normal skin of Cody
So once you first close Cody you got only this home page
so press right here in the South in this Settings button click on it and
Then press on interface settings right here as you can see
So right here press on skin as you can see in the top is the first section
Press on it and here press on skin again
You will got it right here in the state, press on and as you can see
So right here press on yet so that way you got your skin after
Doing everything right?
Does want to load with you don't do that and is gonna work with you?
So here my dear friends we are in the end of the video
Press on subscribe and click on the bell icon to get notified every time I post a new video
Don't forget also to check my videos in the community so that way you can be
Notified about any video. I posted to my community or if you missed any video you will get it on videos
Thanks for watching me and see you tomorrow for another cool rebuild
Don't forget to Like share subscribe to my channel and leave me your comment in the comment sections
-------------------------------------------
SOCIAL MEDIA MESS - Duration: 1:24.
How did we get into this mess that is social media?
You feel worse when you use it.
And you learn to say nothing.
You learn that it's a game, you don't know how to play.
It's a tool you don't know how to use.
You learn that people's profiles and statuses are fake.
They are cultivating it to make their lives seem a certain way
Your head knows better, but your heart doesn't.
You start to see the fakeness but it it doesn't make you feel better.
Even when it's not fake it's an incomplete picture.
It's like looking through rose-colored glasses at their life.
It brings out your neurosis if you try to participate and so you end up just looking
at statuses and you know they're fake but they still have the potential to make you
feel bad about yourself and your life and how you're living it.
USpace is a social network, but it fits my life.
When I have a conversation with my friends it's just between us.
When I share my life, I share it with people I trust.
I like USpace because USpace makes this possible.
I like USpace because it's Private by Default.
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The FRISBEE Upper 90! - Duration: 4:21.
Great penalty actually
When you have something to aim for you just shoot better
I hit the frisbee and dont score
The bladder hits
-------------------------------------------
Clear the Contents of Multiple Outlook Folders - Duration: 0:54.
The utility allows you to delete items in all selected Outlook folders.
For convenience, let's use the Outlook add-in's context menu.
To configure the utility, select one or more Outlook folders.
Run the tool and wait until it finishes.
At the end, the program will report the number of deleted items.
Messages were successfully removed from selected folders to "Deleted Items".
If you want to move Outlook items to a folder other than "Deleted Items" or delete selected folders entirely, use other utilities from us.
-------------------------------------------
Michael Avenatti says he now represents three other women against Donald Trump - Duration: 1:30.
For more infomation >> Michael Avenatti says he now represents three other women against Donald Trump - Duration: 1:30. -------------------------------------------
On some Trips - Duration: 2:06.
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